UTMB Bedrest Campaign 1 Nutritional Status Assessment

MR016G_Campaign_1_Nutritional_Status_Assessment

MR016G

Available online

This dataset contains a collection of the MR016G data resulting from Campaign 1.

UTMB Campaign 1

UTMB Bedrest Campaign 1 Total Fluids

MR016G_Campaign_1_Total_Fluids

MR016G

Available online

This dataset contains a collection of the MR016G data resulting from Campaign 1.

UTMB Campaign 1

Nutritional Status Assessment Before, During, and After Long-Duration Head-Down Bed Rest

JMGROUND_MR016G_2

MR016G

Human

Available online

Text

University of Texas Medical Branch at Galveston (UTMB)

Final Report

Summarized

This article summarizes the nutritional status from 13 subjects participating in 60 or 90 days of head down bed rest. Graphs and tables in the article are as follows: (1) markers of bone metabolism, (2) vitamins, (3) markers of oxidative damage and antioxidants, (4) urine chemistry, (5) blood chemistry, and (6) hematology and iron status before, during, and after bed rest.

Source: Zwart SR, Oliver SAM, Fesperman JV, Kala G, Krauhs J, Ericson K, Smith SM. Nutritional status assessment before, during, and after long-duration head-down bed rest. Aviat Space Environ Med 2009; 80(5,Suppl.):A15-22.

Blood and urine were collected twice before bed rest and about once per month during bed rest. Samples were stored frozed and batch analyzed. Data were analyzed using repeated measurses analysis of variance.

UTMB Campaign 1, UTMB Campaign 3, UTMB Campaign 5

Postural Instability Caused by Extended Bed Rest Is Alleviated by Brief Daily Exposure to Low Magnitude Mechanical Signals

BEDREST0035__2050655144

BEDREST0035

Human

Available online

Text

University of Texas Medical Branch at Galveston (UTMB)

Experiment

Summarized

UTMB Campaign 3, UTMB Campaign 5

Results from Sclerostin Measurements

MR016G__2770823760

MR016G

Human

Available online

University of Texas Medical Branch at Galveston (UTMB)

Experiment

Summarized

Changes in serum sclerostin and bone turnover markers in healthy adult men undergoing controlled bed rest were determined. Seven healthy adult men (31 ± 3 yr old) underwent 90 days of 6 degree head down tilt bed rest at the University of Texas Medical Branch Institute for Translational Sciences-Clinical Research Center.

Serum sclerostin, PTH, vitamin D, bone resorption and formation markers, urinary calcium and phosphorus excretion, and 24-h pooled urinary markers of bone resorption were evaluated before bed rest [baseline (BL)] and at bed rest d 28 (BR-28), d 60 (BR-60), and d 90 (BR-90). Bone mineral density was measured at BL, BR-60, and 5 d after the end of the study (BR+5).

Bone mineral density declined significantly (1-2% per month) at weight-bearing skeletal sites. Serum sclerostin was elevated above BL at BR-28 (+29 ± 20%; P = 0.003) and BR-60 (+42 ± 31%; P < 0.001), with a lesser increase at BR-90 (+22 ± 21%; P = 0.07). Serum PTH levels were reduced at BR-28 (-17 ± 16%; P = 0.02) and BR-60 (-24 ± 14%; P = 0.03) and remained lower than BL at BR-90 (-21 ± 21%; P = 0.14), but did not reach statistical significance. Serum bone turnover markers were unchanged; however, urinary bone resorption markers and calcium were significantly elevated at all time points after bed rest (P < 0.01).

UTMB Campaign 3, UTMB Campaign 5

Cerebral Cortex Plasticity After 90 Days of Bed Rest: Data from TMS and fMRI

NSBRI20010036__2340403140

NSBRI20010036

Human

Available online

Text

January 2010

General Clinical Research Center (GCRC) at University of Texas Medical Branch (UTMB)

Experiment

Summarized

This final report summarizes results for Cerebral Cortex Plasticity After 90 Days of Bed Rest, experiment NNJ04HF70G.

Data summarized in the paper are as follows:

Timeline of study showing the data collection points for transcranial magnetic stimulation (TMS), functional MRI (fMRI), and functional mobility testing (FMT)

Linearity of the transformed recruitment curves

Linear model fits of the recruitment curves across measurement periods

Means and standard errors of the log motor evoked potential (MEP) values across all study measurement periods

Log motor evoked potentials (MEP) correlated with maze performance data

Example of fMRI activation patterns

fMRI percent signal change for single voxel with highest z value

Map of estimated local displacements between scans displayed on the first timepoint scan

Enlarged views of 1st and 2nd scans together with the estimated local volume change between the two, shown as a gray scale % change.

Statistics showing the 8 subjects' volume change maps transformed to a common template

Ground

The following methods were used: transcranial magnetic stimulation (TMS), functional MRI (fMRI), and functional mobility testing (FMT).

UTMB Campaign 3

Results from Testosterone Measurements

MR016G__2770834471

MR016G

Human

Available online

University of Texas Medical Branch at Galveston (UTMB)

Experiment

Summarized

The main objective was to assess testosterone and hormone status in long- and short-duration space flight and bed rest environments and to determine relationships with other physiological systems, including bone and muscle. Blood and urine samples were collected before, during, and after long-duration space flight. Samples were also collected before and after 12- to 14-d missions and from participants in 30- to 90-d bed rest studies. Space flight studies were conducted on the International Space Station and before and after Space Shuttle missions. Bed rest studies were conducted in a clinical research center setting. Data from Skylab missions are also presented.

All of the participants were male, and they included 15 long-duration and nine short-duration mission crew members and 30 bed rest subjects. Serum total, free, and bioavailable testosterone were measured along with serum and urinary cortisol, serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and SHBG. Total, free, and bioavailable testosterone was not changed during long-duration space flight but were decreased (P < 0.01) on landing day after these flights and after short-duration space flight. There were no changes in other hormones measured. Testosterone concentrations dropped before and soon after bed rest, but bed rest itself had no effect on testosterone. There was no evidence for decrements in testosterone during long-duration space flight or bed rest.

UTMB Campaign 3, UTMB Campaign 5

UTMB Bedrest Campaign 1 Clinical Laboratory Assessments

MR010G_Campaign_1_Clinical_Laboratory_Assessment

MR010G

Available online

Processed

This dataset contains data resulting from the Clinical Laboratory Assessment (MR010G) tests performed on three subjects who completed the Campaign 1 Bed Rest Study. MR010G measured subjects' blood and urine periodically four times during the bed rest study.

UTMB Bedrest Campaign 1 Dietary Intake

MR016G_Campaign_1_Dietary_Intake

MR016G

Available online

Experiment

Processed

This dataset contains a collection of the MR016G data resulting from Campaign 1.

UTMB Bedrest Campaign 1 Vascular Function

BRSMVF_Campaign_1_Vascular_Function

BRSMVF

Available online

Experiment

Processed

This dataset contains a collection of pre- and post bed rest muscle strength and endurance data in select muscle groups for the evaluation of in-bed rest countermeasures and post bed rest rehabilitation during the Campaign 1 Bed Rest Study The torque-velocity relationships of the knee extensors and calf plantar flexors will be determined using a Cybex dynamometer. This isokinetic device controls the speed at which a person moves their limb and measures the torque developed when the person tries to move faster than the machine will allow.